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Cephalalgia , 38 (3), 427436

The mechanism by which most drug interactions are determined is a system of liver enzymes called CYP450

The benefits appear to be linked to increased serum Glutathione and benefits are seen within 24 hours of administration but also are persistent and cumulative with additional treatments

In other words, reliance on exogenous glutathione can induce metabolic complications or reduced endogenous production, as the bodys regulatory feedback mechanisms respond, which can cause more problems than the lack of ones own secretion and synthesis of glutathione

When your glutathione levels deplete, you become vulnerable to oxidative stress. This is a state where there is an imbalance between the production of harmful free radicals and the bodys ability to neutralize them

10.1016/j.expneurol.2013.10.002 54 LimJ